Necrotizing Sarcoid Granulomatosis (NSG) is a rare granulomatous illness that primarily affects the lungs and manifests as nodular masses of confluent sarcoid-like granulomas with severe necrosis and vasculitis. It was first described in 1973, as a lung granulomatous disease with sarcoid-like granulomas, vasculitis, and varying degrees of necrosis.
Necrotizing sarcoid granulomatosis is considered a variant of sarcoidosis.
- The condition necrotizing sarcoid granulomatosis is thought to be caused by an autoimmune reaction to an unknown antigen. There is no specific cure for necrotizing sarcoid granulomatosis, but treatment focuses on controlling the underlying inflammation with corticosteroids and other immunosuppressive agents.
- It is characterized by the formation of nodular masses of confluent sarcoid-like granulomas with severe necrosis and vasculitis. The exact cause of the condition is unknown, but it is thought to be related to an autoimmune reaction to an unknown antigen.
- With treatment, most patients are able to achieve remission of their symptoms. However, the condition can recur and may be fatal in some cases. Blood and urine tests are used by healthcare providers, followed by imaging testing.
Necrotizing sarcoid granulomatosis affects more women than men, and the majority of patients are smokers. The age of onset varies, with the majority of cases occurring in the second to sixth decades of life.