About allergic granulomatosis

What is allergic granulomatosis?

Allergic granulomatosis also known as Eosinophilic granulomatosis with polyangiitis (EGPA, formerly Churg-Strauss Syndrome), is a disease that causes inflammation of the blood vessels. This inflammation can reduce blood supply to organs and tissues, causing them to be irreversibly damaged. The most prevalent symptom of adult-onset asthma is wheezing. Nasal allergies, sinus difficulties, rash, gastrointestinal bleeding, and discomfort and numbness in the hands and feet are all possible side effects of the condition. This is a rare condition with no known treatment. Steroids and other potent immunosuppressant medicines can generally manage the symptoms. This is an uncommon condition that can affect a variety of organ systems, particularly the lungs.



What are the symptoms for allergic granulomatosis?

Flu-like symptoms such as fever, a general sensation of Weakness and exhaustion, lack of appetite (anorexia), weight loss, and muscular discomfort are common nonspecific findings linked with allergic granulomatosis. Depending on which organ systems are impacted, additional symptoms and results may occur when suffering from allergic granulomatosis. Peripheral nerves (nerves outside the central nervous system), kidneys, and the gastrointestinal tract are frequently affected in this disorder. Serious organ damage and even life-threatening consequences may occur if proper treatment is not received in time. Although the actual origin of Churg-Strauss syndrome i.e. allergic granulomatosis is uncertain, many experts believe that aberrant immune system activity is a contributing factor for this disorder.



What are the causes for allergic granulomatosis?

Allergic granulomatosis is an allergy that causes inflammation of the blood vessels. This inflammation leads to major passageways getting blocked affecting breathing or swallowing. When an adult develops asthma, it can be a sign of allergic granulomatosis. It is also known as Churg-Straus syndrome or eosinophilic granulomatosis with polyangiitis. The causes of this condition are still unknown. As of now, it is estimated that people suffering from allergic granulomatosis are suffering from some genetic mutation that got triggered by an allergen or the environment. Some other causes can be: an overactive immune system, medications for asthma medications, and medications for leukotriene modifiers. Even though the immune system can trigger inflammation, allergic granulomatosis is not considered to be an autoimmune disorder.



What are the treatments for allergic granulomatosis?

Since allergic granulomatosis is a type of allergic reaction, there are no specific treatments to completely cure the condition. That said, there are certain changes to the lifestyle that one can make in order to keep the conditions in control or from an allergic reaction to be triggered. These lifestyle changes include:


1. Opting for a healthy diet. One of the medications used for treating allergic granulomatosis is corticosteroids. While these medications are not completely curing the condition, they help give relief from the pain and inflammation. But, corticosteroids are known to have side effects like raising the glucose levels in the blood which can lead to diabetes. Hence, having a diet that can keep these changes in check will help make the medications effective without having unwanted side effects.


2. Adding exercises to the daily routine. Exercising is a great way to strengthen the bones and help maintain a healthy weight. Steroids can cause weight gain which adversely affects the entire immune system along with causing cholesterol levels to rise. Working out also prevents the weakening of muscles and vital organs.



What are the risk factors for allergic granulomatosis?

Churg-Strauss syndrome or allergic granulomatosis conditions and risks vary from person to person. For some, the condition gives rise to mild symptoms and basic medications can help keep the condition under control. For others, the condition when triggered can lead to inflammations that can cause suffocation or even death. The condition can affect multiple organs or affect a person on a neurological or just dermatological level. Since it is not clear what causes allergic granulomatosis and the treatment is done via immunosuppressant drugs and/or corticosteroids, these medications also have certain side effects. Opting for a lifestyle change and consulting a doctor when symptoms appear are the best ways to stay safe.



Is there a cure/medications for allergic granulomatosis?

The condition allergic granulomatosis has no known causes and this makes pinpointing any particular mode of treatment difficult. That said, medications can help keep the conditions under control. These include:

Corticosteroids help reduce inflammations. Doctors often prescribe a higher dosage of corticosteroids in order to help the patient get the swelling under control quickly. Medications like Prednisone are prescribed for corticosteroid treatment.

Drugs that act as immunosuppressants are also prescribed to control the immune system’s activities. These drugs are prescribed either with corticosteroids or separately, depending on the severity of the condition. Some examples of immunosuppressive drugs are Mepolizumab, Cyclophosphamide, and Azathioprine.



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